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Dr. Craig

Witz

Director of Clinical Research

BOARD CERTIFIED
Obstetrics and Gynecology
Reproductive Endocrinology and Infertility

281-357-1881

Dr. Craig Witz did his undergraduate studies at Harvard University where he graduated with honors.  He attended medical school at the Baylor College of Medicine in Houston. He completed both his Ob-Gyn residency and Reproductive Endocrinology and Infertility fellowship at The University of Texas Health Science Center at San Antonio.  Dr. Witz remained on the faculty at the UT Health Science Center at San Antonio and served as the Division Head in Reproductive Endocrinology and Infertility and was the Frank Harrison Chair of Reproductive Medicine.  He returned to Houston in 2008 to begin private practice.

Dr. Witz is board certified in Obstetrics and Gynecology, as well as Reproductive Endocrinology and Infertility. He has done extensive research in the area of endometriosis and has won multiple awards for his publications evaluating its pathogenesis. Dr. Witz joined the team at Houston Fertility Institute to assist with the growth of the practice and brings his many years of experience to the care of his patients.

 

Publications

Papers

Witz CA, Silverberg KM, Burns WN, Schenken RS and Olive DL: Complications associated with the absorption of hysteroscopic fluid media. Fertil Steril 60:745-756, 1993.

Burns WN, Witz CA, Klein NA, Silverberg KM and Schenken RS: Serum progesterone concentrations on the day after human chorionic gonadotropin administration and progesterone/oocyte ratios predict in vitro fertilization/embryo transfer outcome. J Assist Reprod Genet 11:17-23, 1994.

Witz CA, Montoya I, Dey TD and Schenken RS: Characterization of lymphocyte subpopulations and T-cell activation in endometriosis. Am J Reprod Immunol 32:173-179, 1994.

Wathen PI, Henderson MC and Witz CA: Abnormal uterine bleeding. Med Clin North Am 79:329-344, 1995.

Witz CA, Klein N and Schenken RS: Resident Leukocytes in Endometriosis. Proceedings of the Vth World Congress on Endometriosis. Yokohama, Japan. Parthenon Publishing, October 21-24, 1996.

Witz CA and Schenken RS: Pathogenesis of Endometriosis. Semen Reprod Endocrinol 15:199-208, 1997.

Witz CA, Montoya IA, Miller DM, Schneider B and Schenken RS: Mesothelial expression of integrins in vivo and in vitro. J Soc Gynecol Invest 5:87-93, 1998.

Potter DA, Witz CA, Burns WN, Brzyski RG and Schenken RS: Endometrial biopsy during hormone replacement cycle in donor oocyte recipients before in vitro fertilization-embryo transfer. Fertil Steril 70:219-222, 1998.

Witz CA, Montoya IA and Schenken RS: Whole explants peritoneum and endometrium: a novel model of the early endometriosis lesion. Fertil Steril 71:56-60, 1999.

Witz CA, Duan Y, Burns WN, Atherton S and Schenken RS: Is there a risk of cytomegalovirus transmission during in vitro fertilization with donated oocytes? Fertil Steril 71:302-307, 1999.

Witz CA: Current concepts in the pathogenesis of endometriosis. Clin Obstet Gynecol 42:566-585, 1999.

Witz CA, Montoya-Rodriguez IA and Schenken RS: What is the most appropriate phase of endometrium to use for peritoneal attachment studies (letter). Fertil Steril 72:381-382, 1999.

Witz CA: Interleukin-6: Another piece of the endometriosis cytokine puzzle. Fertil Steril 73:212-214, 2000.

Witz CA, Takahashi A, Montoya-Rodriguez IA, Cho S and Schenken RS: Expression of the 21 and 31 integrins at the surface of meosthelial cells: a potential attachment site of endometrial cells. Fertil Steril 74:579-584, 2000.

Witz CA, Thomas MR, Montoya-Rodriguez IA, Nair AS, Centonze VE and Schenken, RS: Short-term culture of peritoneum explants confirms attachment of endometrium to intact peritoneal mesothelium. Fertil Steril 75:385-390, 2001.

Witz CA and Schenken RS. Attachment of endometrial cells to peritoneum – facilitated? (letter). Fertil Steril 76:421-422, 2001.

Witz CA and Schenken RS. Attachment of “menstrual” endometrium to peritoneum? (letter). Fertil Steril 76:642-643, 2001.

Witz CA, Montoya-Rodriguez IA, Cho S, Centonze VE, Bonewald LF and Schenken RS: Composition of the extracellular matrix of the peritoneum. J Soc Gynecol Invest 8:299-230, 2001.

Dechaud H, Witz CA, Montoya-Rodriguez IA, Degraffenried L and Schenken,R.S. Mesothelial cell-associated hyaluronic acid facilitates endometrial stromal and epithelial cell binding to mesothelium. Fertil Steril 76:1012-1018, 2001.

Witz CA and Burns WN. Endometriosis and infertility: Is there a cause and effect relationship? Gynecol Obstet Invest 53(s):2-11, 2002.

Witz CA. Pathogenesis of Endometriosis. Gynecol Obstet Invest 53(s):52-62, 2002.

Witz CA, Dechaud H, Montoya-Rodriguez IA, Thomas MR, Nair AS, Centonze VE and Schenken RS. An in vitro model to study the pathogenesis of the early endometriotic lesion. Ann NY Acad Sci 955:296-307, 2002.

Witz CA, Allsup K, Vaughn SL, Montoya-Rodriguez IA, Centonze VE and Schenken RS: Culture of menstrual endometrium with peritoneal explants and mesothelial monolayers confirm attachment to intact mesothelial cells. Hum Reprod 17: 2832-2838, 2002.

Witz CA, Cho S, Montoya-Rodriguez IA and Schenken RS: The 21 and 31 integrins do not mediate attachment of endometrial cells to peritoneal mesothelium. Fertil Steril 78:796-803, 2002.

Witz CA, Allsup KT, Montoya-Rodriguez IA, Vaughan SL, Centonze VE and Schenken RS: Pathogenesis of endometriosis – current research. Hum Fertil 6:34-40, 2003.

Witz CA. Cell adhesion molecules in endometriosis. Sem Reprod Endocrinol 21:173-181, 2003.

Witz CA, Cho S, Centonze VE, Montoya Rodriquez IA, Schenken RS. Time series analysis of transmesothelial invasion by endometrial stromal and epithelial cells using three-dimensional confocal microscopy. Fertil Steril 79:770-778, 2003.

Lucidi RS, Chrisco MA, Shain, SA, Binkley PA, Holden AE and Witz CA. A novel assay demonstrates that the variability of endometrial stromal cell binding to mesothelium is dependent on the source of endometrium. Fertil Steril 84:16-21, 2005

Lucidi RS, Witz CA, and Schenken RS. Modeling endometriosis. Fertil Steril 84:39, 2005

Lucidi RS, Pierce JD, Kavoussi S and Witz CA. Prior fertility in the male partner: a predictor of normal semen analysis? Fertil Steril 84:,793-794, 2005

Young P, Johns, A, Templeman, C, Witz CA, Webster, B, Ferland, R, Diamond, MP, Block, Kathleen, diZerega, Gere. Reduction of postoperative adhesions after laparoscopic gynecological surgery with Oxiplex/AP Gel: a pilot study. Fertil Steril 84(5): 1450-6, 2005.

Nair AS, Nair HB, Lucidi RS, Kirchner AJ, Schenken RS, Tekmal RR, Witz CA. Modeling the Early Endometriotic Lesion: Mesothelium-Endometrial Cell Coculture Increases Endometrial Invasion and Alters Mesothelial and Endometrial Gene Transcription. Fertil Seril 90(suppl 4): 1487-95, 2008.

Ferreira M, Witz CA, Hammes L, Kirma N, Petraglia F, Schenken RS, Reis F. Activin A increases invasion of endometrial stromal and epithelial cells into modeled human peritoneum. Mol Hum Reprod 14:301-7, 2008

Vaz-Silva J, Carneiro MM. Ferreira MC, Pinheiro SV,. Silva DA,. Silva-Filho AL, Witz CA,. Reis AM., Santos RA. Reis FM The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reprod Sci:.16:247-56, 2009.

Peroxisome proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. Kavoussi SK, Witz CA, Lebovic DI. Molec Hum Reprod, 15(10):687-92, 2009

Jensen JR, Witz CA, Schenken RS, Tekmal RR. A potential role for colonystimulating factor 1 in the genesis of the early endometriotic lesion. Fertil Steril 93(1):251-6,2010

Griffith JS, Binkley PA, Kirma NB, Schenken RS, Tekmal RR, Witz CA. Imatinib Decreases Endometrial Stromal Cell Transmesothelial Migration and Proliferation in the Extracellular Matrix of Modeled Peritoneum. Fertil Steril, 94:2531-5, 2010

Cetrorelix lowers premature luteinization rate in gonadotropin ovulation induction-intrauterine insemination cycles: a randomized-controlled clinical trial. Steward RG, Gill I, Williams DB, Witz CA, Griffith J, Haddad GF. Fertil Steril 95:434-6, 2011

Liu J, Wang W, Sun X, Liu L, Jin H, Li M, Witz C, Williams D, Griffith J, Skorupski J, Haddad G, Gill J. DNA microarray reveals that high proportions of human blastocysts from women of advanced maternal age are aneuploid and mosaic. Biol Reprod 2012

Optimized protocol for cryopreservation of human eggs improves developmental competence and implantation of resulting embryos in humans Wang CT, Liang L, Witz C, Williams D, Jason Griffith JS , Skorupski JS, Haddad G, Gill IO and Wang W. J Ov Res, in press Liang L, Wang W, Sun X, Liu L, Jin H, Li M, Witz C, Williams D, Griffith J, Skorupski J, Haddad G, Gill J. dentification of chromosomal errors in human preimplantation embryos with oligonucleotide DNA microarray. In Press

Chapters:

Honoré GM and Witz CA: Contraception. IN: The Clinics Atlas of Office Procedures – Office Gynecology, J. Appleby and K.R. Montella (Eds.), W. B. Saunders, Philadelphia, PA, Vol. 1 No. 1, pp. 89-107, 1998.

Witz CA and Honoré GM: Evaluation and Treatment of Abnormal Uterine Bleeding. IN: The Clinics Atlas of Office Procedures – Office Gynecology, J. Appleby and K.R. Montella (Eds.), W. B. Saunders, Philadelphia, PA, Vol. 1 No.1, pp. 139-161, 1998.

Witz, C.A., Cho, S., Centonze, V.E., Montoya-Rodriguez, I.A. and Schenken, R.S.: Time series analysis of transmesothelial invasion by endometrial stromal and epithelial cells using three-dimensional confocal microscopy. Proceeding of the Microscopy and Microanalysis, G.W. Bailey, R.L. Price, E. Voelkl and I.H. Musselman (Eds.), Springer-Verlag New York, Inc., New York, New York, Vol. 7, Suppl 2, pp. 580-581, 2001.

Witz, C. A. Pathogenesis of endometriosis. IN: Endometriosis in Clinical Practice. Olive, D.L. ed. Taylor & Francis , Andover, Hampshire, UK, pp. 61-78, 2005.

Lucidi RS and Witz CA. Endometriosis. IN: Requisites in Obstetrics and Gynecology: Reproductive Endocrinology and Infertility. Elesevier, Philadelphia, Pennsylvania, In press.

Abstracts:

Silverberg KM, Dey T, Witz CA and Schenken RS: The modified D-Mannose in vitro binding assay (MBA) predicts fertilization in vitro. Presented at the Combined 49th Annual Meeting of The American Fertility Society and the 39th Annual Meeting of the Canadian Fertility and Andrology Society, Montreal, Canada, October 9-14, 1993.

Witz CA, Chang P, Montoya IA, Dey TD and Schenken RS: Characterization of resident lymphocyte subpopulations and T-cell activation in endometriosis. Presented at the 41st Annual Meeting of The Society for Gynecologic Investigation, Chicago, Illinois, March 22-26, 1994.

Witz CA, Montoya IA, Miller DA, Schneider B and Schenken RS: Mesothelial expression of integrins in vivo and in vitro. Presented at the 42nd Annual Meeting of The Society for Gynecologic Investigation, Chicago, Illinois, March 15-18, 1995.

Witz CA, Montoya IA, Norris CJ and Schenken RS: Mesothelium integrins in peritoneum explant culture. Presented at the 43rd Annual Meeting of The Society for Gynecologic Investigation, Philadelphia, Pennsylvania, March 20-23,1996.

Potter DA, Witz CA, Burns WN, Brzyski RG and Schenken RS: Endometrial biopsy during hormone replacement cycle in recipients prior to in vitro fertilization – embryo transfer with donated oocytes. Presented at the 52nd Annual Meeting of the American Society for Reproductive Medicine, Boston, Massachusetts, November 2-7, 1996.

Witz CA, Montoya IA, Doucet RV, Bonewald LF and Schenken RS: Tumor necrosis factor- increases endometrial stromal cell adhesion to extracellular matrix proteins. Presented at the 44th Annual Meeting of the Society for Gynecologic Investigation, San Diego, California, March 19-22, 1997.

Witz CA, Doucet V, Honoré GM, Montoya IA, Bonewald LF and Schenken RS: Preferential endometrial stromal cell adhesion to collagen IV and collagen I is inhibited by echistatin. Presented at the 53rd Annual Meeting of the American Society for Reproductive Medicine, Cincinnati, Ohio, October 18-22, 1997.

Witz CA, Duan Y, Potter DA, Honoré GM and Schenken RS: Is there a risk of CMV transmission during in vitro fertilization with donated oocytes? Presented at the 53rd Annual Meeting of the American Society for Reproductive Medicine, Cincinnati, Ohio, October 18-22, 1997.

Witz CA, Montoya-Rodriguez IA, Chen E, Bonewald LF and Schenken RS: Composition of the extracellular matrix in the peritoneum. Presented at the 45th Annual Meeting of the Society for Gynecological Investigation, Atlanta, GA, March 11-14, 1998.

Schenken RS, Witz CA and Klein NA: Leukocyte Infiltration. Presented at the VI World Congress on Endometriosis, Quebec City, Canada, June 30-July 4, 1998.

Witz CA, Takahashi A, Montoya-Rodriguez IA, Fellows J and Schenken RS: Expression of the 2ß1 and 3ß1 integrins at the surface of mesothelial cells: a potential attachment site of endometrial stromal cells. Presented at the Annual Meeting of the American Society for Reproductive Medicine, Toronto, Canada, September 25-30, 1999.

Witz CA, King MR, Nair AS, Montoya-Rodriguez IA, Miller MM and Schenken RS: Short-term culture of peritoneum explants confirms attachment of endometrium to intact mesothelium. Presented at the 47th Annual Meeting for the Society for Gynecologic Investigation, Chicago, IL, March 23-25, 2000.

Thyer A, Brzyski RB, Witz CA, Honoré GM, Loret de Mola JR and Schenken and RS: Insulin and glucose responses to metformin correlate with ovulation in clomiphene-resistant women with polycystic ovary syndrome. Presented at the 56th Annual Meeting of the American Society for Reproductive Medicine, San Diego, California, October 21-25, 2000.

Witz CA, Cho S, Centonze VE, Montoya-Rodriguez IA and Schenken RS: Time series analysis of transmesothelial invasion by endometrial stromal and epithelial cells using three-dimensional confocal microscopy. Presented at the 56th Annual Meeting of the American Society for Reproductive Medicine, San Diego, California, October 21-25, 2000.

Dechuad H, Witz CA, Montoya-Rodriguez IA and Schenken RS: Mesothelial cell associated hyaluronic acid facilitates endometrial stromal and epithelial cell binding to mesothelium cells. Presented at the 56th Annual Meeting of the American Society for Reproductive Medicine, San Diego, California, October 21-25, 2000.

Witz CA, Cho S, Montoya-Rodriguez IA and Schenken RS: The 21 and 31 integrins do not mediate attachment of endometrial cells to peritoneal mesothelium. Presented at the 48th Annual Meeting for the Society for Gynecologic Investigation, Toronto, ON Canada, March 14-17, 2001.

Witz CA, Dechaud H, Montoya-Rodriguez IA, Thomas MR, Nair AS, Centonze VE and Schenken RS: An in vitro model to study the pathogenesis of the early endometriotic lesion. Presented at the NICHD Endometriosis Workshop, Bethesda, Maryland, April 9-10, 2001.

Witz CA, Cho S, Centonze VE, Montoya-Rodriguez IA and Schenken RS: Time series analysis of transmesothelial invasion by endometrial stromal and epithelial cells using three-dimensional confocal microscopy. Presented to the “Cell Biology of Cancer” for the Microscopy and Microanalysis Meeting Management, Long Beach, California, August 5-9, 2001.

Witz CA, Vaughn SL, Frieden BE, Montoya-Rodriguez IA, Centonze VE and Schenken RS: Culture of menstrual endometrium with peritoneal explants and mesothelial monolayers confirm attachment to intact mesothelial cells. Presented at the 57th Annual Meeting of the American Society for Reproductive Medicine, Orlando, Florida, October 20-25, 2001.

Brzyski RG, Witz CA, Eddy CA, Pierce JD, Binkley PA and Schenken, RS: Association between donor gamete use and choice of embryo donation for final disposition of cyropreserved embryos. Presented at the 57th Annual Meeting of the American Society for Reproductive Medicine, Orlando, Florida, October 20-25, 2001.

Witz CA, Montoya-Rodriguez IA, Centonze VE, Schenken RS. Menstrual endometrium and individual endometrial stromal and epithelial cells are unique in their ability to adhere to and invade peritoneal mesothelium. Presented at the 58th Annual Meeting of the American Society of Reproductive Medicine, Seattle, Washington, October 12-17, 2002.

Witz CA, Montoya-Rodriguez IA, Centonze VE and Schenken RS. Modelling the early endometriosis lesion: examination of endometrial cell and mesothelial cell interactions. Presented at the 36th Annual Meeting of the Society for the Study of Reproduction, Cincinnati, Ohio, July 19-22, 2003.

Lucidi RS, Pierce JD, Kavoussi S and Witz CA. Prior fertility in the male partner: a predictor of normal semen analysis? Presented at the 59th Annual Meeting of the American Society for Reproductive Medicine, San Antonio, Texas, October 11-15, 2003.

Lucidi RS, Chrisco MA, Shain, SA, Binkley PA, Holden AE and Witz CA. A novel assay demonstrates that the variability of endometrial stromal cell binding to mesothelium is dependent on the source of endometrium. Presented at the 51st Annual Meeting of the Society for Gynecologic Investigation, Houston, Texas, March 24-27, 2004.

Liu Y, Jones J, Lucidi RS, Witz CA, Schenken RS and Tekmal RR. Tumor necrosis factor-alpha (TNF-alpha) induces peritoneal mesothelial (PMC), endometrial epithelial (EEC) and endometrial stromal (ESC) cell expression of genes involved in invasion and metastasis. Presented at the 60th Annual Meeting of the American Society for Reproductive Medicine, Philadelphia, Pennsylvania, October 16-20, 2004.

Witz CA, Lucidi RS, Centonze VE, Liu Y, Jones J and Tekmal RR. Characterization of a novel three-dimensional model of the early endometriotic lesion. Presented at the 60th Annual Meeting of the American Society for Reproductive Medicine, Philadelphia, Pennsylvania, October 16-20, 2004.

Lucidi RS, Jones J, Witz CA, Binkley PA, Tekmal RR and Schenken RS. Peritoneal mesothelial cell co-culture with endometrial cells increases mesothelial cell expression of macrophage colony-stimulating factor. Presented at the Annual Meeting of the American Society for Reproductive Medicine, Philadelphia, Pennsylvania, October 16-20, 2004.

Nair AS, Lucidi RS, Binkley PA, Tekmal RR, Schenken RS, Witz CA. Protein Kinase C (PKC) – Dependent Signaling Pathways Promote Genesis of the Early Endometriotic Lesion. Presented at the Annual Meeting of the American Society for Reproductive Medicine, Montreal, Quebec, October, 2005

Lucidi RS, Liu Y, Robinson R, Tekmal RR, Schenken RS, Witz CA. Colony stimulating factor-1 promotes endometrial cell migration and proliferation in twoand three-dimensional culture. Presented at the Annual Meeting of the American Society for Reproductive Medicine, Montreal, Quebec, October, 2005

Nair AS, Holden A, Brzyski RG, Tamimi H, Thyer A, Witz CA. Risk Factors for Depression in Patients with Polycystic Ovarian Syndrome Vary by Ethnicity. Presented at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, 2006

Nair AS, Witz CA, Nair HB, Tekmal RR, Schenken RS. Inhibition of CD44 NLinked Glycosylation Inhibits Endometrial Cell Binding to Peritoneal Mesothelial Cells. Presented at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, 2006

Nair AS, Lucidi RS, Ferriera MC, Nair HB, Tekmal RR, Witz, CA. Endometrial Cell Binding to Mesothelial Cells Enhances Invasion of Endometrial Cells In a 3-Dimensional Model of Human Peritoneum. Presented at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, 2006

Ferreira MC, Hammes LS, Kirma N, Schenken RS, Reis FM, Witz CA. Activin-A Increases Invasion of Endometrial Stromal Cells and Endometrial Epithelial Cells into Modeled Human Peritoneum. Presented at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, 2006

Lucidi RS, Berria R, Witz CA, Easton CA, Brzyski RG, Defronzo RA. Effect of Pioglitazone on hormonal parameters and ovulation in women with polycystic ovary syndrome. Presented at the Annual Meeting of the American Society for Reproductive Medicine, New Orleans, Louisiana, 2006

Kavoussi SK, Nair AS, Witz CA, Lebovic DI. PPAR-γ Activation Decreases Attachment of Endometrial Cells to Peritoneal Mesothelial Cells in an In Vitro Model of the Early Endometriotic Lesion. Presented at the Annual Meeting of the Society for Gynecologic Investigation, Reno Nevada, March 14-17, 2007

Griffith JS, Binkley PA, Kirma NB, Schenken RS, Tekmal RR, Witz CA. Imatinib Decreases Endometrial Stromal Cell Transmesothelial Migration and Proliferation in the Extracellular Matrix of Modeled Peritoneum. Presented at the 63rd Annual Meeting of the American Society for Reproductive Medicine, Washington, D.C., 2007.

Griffith JS, Liu YG, Witz CA, Tekmal RR, and Schenken RS. Menstrual Endometrial Cells from Women with Endometriosis Demonstrate Increased Binding to Peritoneal Mesothelial Cells and Express Several CD44 Splice Variants. Presented at the 63rd Annual Meeting of the American Society for Reproductive Medicine, Washington, D.C., 2007.

Jensen JR, Rao PP, Tekmal RR, Schenken RS, and Witz CA. An In Vivo Model Suggests that Colony Stimulating Factor-1 Plays a Critical Role in the Genesis of the Early Endometriotic Lesion. Presented at the 63rd Annual Meeting of the American Society for Reproductive Medicine, Washington, D.C., 2007.

Vaz-Silva J, Carneiro MM, Ferreira MC, Reis AM, Witz CA, Reis FM. Angiotensin (1-7) and Its Receptor MAS Expressed in Human Endometrium During the Menstrual Cycle. Presented at the 63rd Annual Meeting of the American Society for Reproductive Medicine, Washington, D.C., 2007.

Video Presentations

A model of the early endometriotic lesion using three-dimension confocal laser scanning microscopy. Presented at the 57th Annual Meeting of the American Society for Reproductive Medicine. Orlando, Florida October 20-25, 2001.

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